| |
|
|
| |
|
|
Type A Blood Converted To Universal Donor Blood With Help From Bacterial Enzyme
For a transfusion to be successful, the patient and donor blood types must be compatible. Now, researchers analyzing bacteria in the human gut have discovered that microbes there produce two enzymes that can convert the common type A into a more universally accepted type. If the process pans out, blood specialists suggest it could revolutionize blood donation and transfusion. To up the supply of universal blood, scientists have tried transforming the second most common blood, type A, by removing its "A-defining" antigens. But they've met with limited success, as the known enzymes that can strip the red blood cell of the offending sugars aren't efficient enough to do the job economically.
After 4 years of trying to improve on those enzymes, a team led by Stephen Withers, a chemical biologist at the University of British Columbia (UBC) in Vancouver, Canada, decided to look for a better one among human gut bacteria. Some of these microbes latch onto the gut wall, where they "eat" the sugar-protein combos called mucins that line it. Mucins' sugars are similar to the type-defining ones on red blood cells. So UBC postdoc Peter Rahfeld collected a human stool sample and isolated its DNA, which in theory would include genes that encode the bacterial enzymes that digest mucins. Chopping this DNA up and loading different pieces into copies of the commonly used lab bacterium Escherichia coli, the researchers monitored whether any of the microbes subsequently produced proteins with the ability to remove A-defining sugars. At first, they didn't see anything promising. But when they tested two of the resulting enzymes at once -- adding them to substances that would glow if the sugars were removed -- the sugars came right off. The enzymes also worked their magic in human blood. Tiny amounts added to a unit of type A blood could get rid of the offending sugars, they found.
The findings have been reported today in the journal Nature Microbiology. |
|
|
|
| |
|
| There are no conversations. |
| |
|
|
| cauz |
June 11, 2019, 12:53 p.m. |
| |
|
|
|
| Stephen Daldry |
In issues of recent ethnic wars and genocides - particularly if you look at Darfur - one of the most remarkable things is our inability to act, still, despite the years of analyzing and re-analyzing what it does to subsequent generations. We still find a massive inability to step in and step up to the plate, when genocide is happening as we speak. |
| Naveen Jain |
Trust your gut instinct over spreadsheets. There are too many variables in the real world that you simply can't put into a spreadsheet. Spreadsheets spit out results from your inexact assumptions and give you a false sense of security. In most cases, your heart and gut are still your best guide. |
| Thomas R. Insel |
Unlike the heart or kidney, which have a small, defined set of cell types, we still do not have a taxonomy of neurons, and neuroscientists still argue whether specific types of neurons are unique to humans. But there is no disputing that neurons are only about 10 percent of the cells in the human brain. |
| Johnny Cash |
You've got a song you're singing from your gut, you want that audience to feel it in their gut. And you've got to make them think that you're one of them sitting out there with them too. They've got to be able to relate to what you're doing. |
| Roshon Fegan |
I started playing drums at about seven or eight. My mom used to let me play with the pots and pans, and instead of telling me to stop like most moms would, she just let me do it. So the noise kind of turned into music. From that point on, musically, that's what I want to do: start creating beats. |
| Orison Swett Marden |
Your expectations opens or closes the doors of your supply, If you expect grand things, and work honestly for them, they will come to you, your supply will correspond with your expectation. |
| Bryan Adams |
I've only ever trusted my gut on everything. I don't trust my head, I don't trust my heart, I trust my gut. |
| Anthony Fauci |
Pneumococcal disease is a real threat. Pneumococcal disease is a bacterial infection that causes anything from middle ear infection to pneumonia to meningitis. Children are particularly vulnerable to it, but adults can get pneumococcal disease themselves. |
| Carrie Ann Inaba |
One of the best gifts you can give to an animal is a donation of a blanket to your local animal shelter during the winter months. |
| Dwight L. Moody |
Church attendance is as vital to a disciple as a transfusion of rich, healthy blood to a sick man. |
|
|
|
|
|
I had a dream that I was asleep and kept waking up in pools of blood around my head like I was drooling blood or something. After a while I stood up and all this stuff started falling out of my mouth. Like teeth and blood and flesh and all sorts of stuff.
|
| |
|
|
|
|
I had a dream that someone broke into someone else's house and this guy had a gun and he shot the person and it turns out it was a kid and the kid died and his blood spattered everywhere and there was this other kid that lived there and I just remember how that kid looked with the spatter of some other kids blood all over him.
|
| |
|
|
|
t is well known that a high salt diet leads to high blood pressure, a risk factor for an array of health problems, including heart disease and stroke. But over the last decade, studies across human populations have reported the association between salt intake and stroke irrespective of high blood pressure and risk of heart disease, suggesting a missing link between salt intake and brain health.
Interestingly, there is a growing body of work showing that there is communication between the gut and brain, now commonly dubbed the gut–brain axis. The disruption of the gut–brain axis contributes to a diverse range of diseases, including Parkinson’s disease and irritable bowel syndrome. Consequently, the developing field of gut–brain axis research is rapidly growing and evolving. Five years ago...
|
| |
|
|
|
|
"Feeding an Appetite-Suppressing Human Drug To Mosquitos Make Them Lose Their Attraction To Blood By Around 80%: Study"
|
| |
|
|
|
so if you write with someone else's blood, not a lot is cool?
This post is a comment.
|
| |
|
|
|
Like the first hood is menacing enough you know? But when he takes it up to level two thats when the blood starts flyin.
This post is a comment.
|
| |
|
|
|
|
I had a dream that I was at some sort of wedding in a country I didn't recognize. They had all these strange traditions that I was trying to figure out and participate in but I had no idea what I was doing. Everyone was wearing a blue, red, or tan colored robe. I was wearing a tan one and people were in groups. I was supposed to be in a group but I couldn't figure out which one. I had some realization that my group must have left already. I didn't know where they were going but I ran out of this room and there was a big glass elevator. There was a guy frantically pointing at the patterns on the tile floor and rambling about the elevator. Three people stood in front of the elevator, me and two women. One women saw this guy and stepped back and the other woman and I got on the elevator. It went down nearly to the bottom and then started moving up again and suddenly fell off the cables and crashed two or three stories below. I crawled out of what was left of the elevator covered in blood...
|
| |
|
|
|
Maybe more like giant worms. Like... way bigger than blood vessels. We were also upstairs at my grandmas house so that was weird.
This post is a comment.
|
| |
|
|
|
|
"When you're writing with your own blood, it's not impressive if you don't write a lot" - wise words of Dr. Coke
|
| |
|
|
|
For our struggle is not against flesh and blood, but against the rulers, against the authorities, against the powers of this dark world and against the spiritual forces of evil in the heavenly realms.
—Ephesians 6:12
|
| |